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Fig. 7. GnRH neuron distribution in the hypothalamus of adult reeler,
scrambler and ApoER2/Vldlr mutant mice. (A,B) Sagittal sections
taken from adult wild-type and reeler animals, respectively (A) Typical
distribution of GnRH neurons in the hypothalamus. (B) In the reeler
mouse there are very few, faintly stained GnRH neurons. At this magnification,
GnRH neurons are hardly visible in reeler. The inset B', taken
from the area indicated by an asterisk in B, illustrates a few of these
neurons at a higher magnification. (C) A profuse array of GnRH processes
(arrowheads) streaming to the median eminence (me) region from an adult
wild-type animal. In reeler mice (D), only very few such processes
(arrowheads) converge to the median eminence. (E,F) Sections taken from the
brains of ApoER2/Vldlr mutants (E) and scrambler mice (F)
illustrate that the density and appearance of GnRH neurons are similar to
those in wild-type animals. Scale bars: 100 µm (A,B,E,F); 50 µm
(B9,C,D). mpoa, medial preoptic area; db, diagonal band of Broca; me, median
eminence; so, supraoptic nucleus.
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