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Fig. 6. Tead-Yap complex activates the CE in P19 cells. (A) Transfection assay showing activation of 8xCE reporter by co-transfection of Tead and Yap expression vectors. The reporter is indicated in the upper left corner of each panel. Combinations of Tead and Yap effectors are indicated below the panel. (B) The Tead binding site is required for activation of the CE by Tead-Yap complex. Mutation of the Tead-binding site (M4) abolished activation by Tead-Yap. (C) Transcriptional activity of Tead is not increased in ß-catenin-expressed P19 cells. By contrast to the activation of 8xCE, the authentic Tead-binding site (8xGT-IIC) was not activated in ß-catenin-expressed cells.





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