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Fig. 1. Comparisons of Hr-POPK-1 with homologs in other animals. Hr-POPK-1 shows
high similarity to Cs-SAD-1 of C. elegans (Accession No. AB014885),
Mm-SAD-A of mouse (Accession No. AY533671), Hs-SAD1 of human (Accession No.
BC016681) and CG6144 of Drosophila melanogaster (Accession No.
NM135570). Humans have at least three other homologs in the genome. These
proteins share an N-terminal kinase domain (orange). The amino acid identity
compared with Hr-POPK-1 is indicated in the diagrams. They had two other
conserved domains (blue), whose function is unknown. Hr-POPK-1 and PAR-1 of
C. elegans show lower similarity in their kinase domains, and PAR-1
has no similarity outside the kinase domain. Numbers on the right side
indicate the number of total amino acid residues.
