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Fig. 1. Activity of Ap-2Cre revealed using Rosa-26 reporter mice. Ages of embryos are as indicated. (A) Whole embryo at the 20-somite stage. (B) Forelimbs at the 20 (left) and 28 (right)-somite stage. The embryo in B was slightly bigger than embryo in A. (C) Forelimbs of embryos at the 32 (left) and 36 (right)-somite stage. (D) Hindlimb of an E10.5 embryo (32 somites). (F) Section of E11.5 forelimbs. (G) Whole-mount in situ hybridization of E11.5 forelimbs using a probe for Fgfr1. Genotypes of the embryos were: mutant (Mt) Fgfr1Co/Co;Ap-2Cre and controls (Wt) Fgfr1Co/Co. FL, forelimb; HL, hindlimb; AER, apical ectodermal ridge; a, anterior; p, posterior.





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