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Fig. 7. Phenotypes of forelimbs of Fgfr1Co/Co;Hoxb6-Cre mice. Whole-mount in situ hybridization using probes as indicated. Ages of limb buds were E11.5 (A,B), E12.25 (C), E12.5 (D,E), E14.5 (F) and P21 (G). Arrowheads in A-E indicate the border between the relatively normal anterior and the abnormal posterior portions of the limbs. The mutant limb bud shown in C is placed at two different angles to show a reduced height for the PD axis (middle) and an increased length of the DV axis (right). Wt, wild type; Mt, mutant.





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