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Fig. 7. Ablation of RALDH1 and RALDH3 impairs programmed cell death and
differentiation in the periocular mesenchyme. (A,B,D,E) Distribution of
apoptotic cells (assessed by TUNEL assays) in E11.5 wild-type (A,B) and
Aldh1a1/3-null (D,E) fetuses. (C,F,G-N) In situ hybridization with
digoxigenin-labeled Eya2 (C,F), Foxc1 (G,K), Pitx2
(H,L) Fgfr2 (I,M) and Pax6 (J,N) antisense riboprobes on
frontal sections through the eye of E11.5 wild-type (C,G,H,I,J) and
Aldh1a1/3-null (F,K,L,M,N) fetuses. Note that the histological
sections illustrated have been selected to provide the best match between
mutant and wild-type embryos. Red brackets indicate the periocular mesenchyme.
d, dorsal retina; le, lens; o, optic nerve; rpe, retinal pigment epithelium;
v, ventral retina. Scale bar: 50 µm.
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