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Fig. 6. Expression of SMAD4^100T suppresses wing phenotypes generated by dominant-negative Drosophila TCF. (A) UAS.DN-TCF/MS1096.Gal4 wing is only 10% of the size of a wild-type wing and has no margin. (B) UAS.DN-TCF/MS1096.Gal4 wing with two copies of UAS.SMAD4^100T is roughly three-fold larger than the wing in A, and the anterior margin is restored. Transformation of Twin Sensillum One into a bristle is noted (arrowhead). (C) UAS.DN-TCF/MS1096.Gal4 wing with three copies of UAS.SMAD4^100T is roughly four-fold larger than the wing in A, and the anterior margin is restored. Sensillum-to-bristle transformation is noted (arrowhead). (D) UAS.SMAD4^100T/MS1096.Gal4 wing has a normal margin and two sensilla-to-bristle transformations (arrowheads). (E) Wing with MS1096.Gal4 driving two copies of UAS.SMAD4^100T has a normal margin, sensilla-to-bristle transformation (arrowhead) and vein defects. (F) Wing with MS1096.Gal4 driving three copies of UAS.SMAD4^100T has a reduced size, a normal margin, sensilla-to-bristle transformation (arrowhead) and vein defects.

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