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Fig. 4. Morphological changes of external ear pinna in conditional Hoxa2 mutant mice. (A-F) Analysis of the external ear phenotype in newborn mice. Lateral view of the head of wild-type (A), Hoxa2–/– (B) and Hoxa2flox/flox;Wnt1-Cre (C), as well as Hoxa2flox/flox;Cre-ERT2 (D) and Hoxa2del/flox;Cre-ERT2 (E,F) newborn mice treated with tamoxifen (TM) at various stages, as indicated between brackets. The arrows show absent (B-E) or hypoplastic (F) ear pinna in mutant mice, according to the stage of induction. P, pinna.





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