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Fig. 6. Mispatterning and retarded migration of neural crest cells in E9.5-E10.5
Msx1/2 mutant embryos. (A-P) Lateral views of E9.5 (A-H) and
E10.5 (I-P) embryos hybridized with digoxigenin-labeled RNA probes for
Ap-2
(A-D,I-L), Sox10 (E,F,M-P) and cdh6
(G,H). Note the abnormal expression in mutants of each marker at the level of
r3, as indicated by arrowheads (B,F,H,N). Also note the retarded production
and migration of neural crest cells from rhombomeres 2, 4, 6 and 7 at E9.5
(B,D). Ap-2 and Sox10 expression in the trigeminal
ganglion was significantly reduced (B,F,J,N arrows). In mutant embryos,
merging of the migrating neural crest from r6 and r7 at E9.5 (D,F,H) results
in the fusion of neural crest streams migrating into third and fourth arch
arteries at E10.5 (asterisk in L,P). Boxed areas in I and J are shown at
higher magnification in K and L. Scale bars: in A (for A,B), C (for C,D), F
(for E,F), H (for G,H), 0.2 mm; in J (for I,J), L (for K,L), N (for M,N), P
(for O,P), 0.4 mm.
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