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Fig. 7. Altered expression of Krox20 and Epha4 in
Msx1/2 mutant hindbrain. Whole-mount in situ hybridization
analysis of E8.5 and E9.5 embryos with the indicated probes. (A-F) Expression
of Krox20 at E8.5 (A-D) and E9.5 (E,F). The box in A and B demarcates
the region shown in C and D. Note the reduction in the level of
Krox20 transcripts in the caudal portion of r5 in mutant embryo at
E8.5 (B,D), but normal expression at E9.5 (F). (G-L) Expression patterns of
Hoxb1 in r4 (G,H), Hoxd4 in the region caudal to r7 (I,J),
and Crabp1 from r2 to r6 (K,L) at E9.5 show no apparent change in the
mutant hindbrain. (M-P) Epha4 expression at E9.5. Enlarged view of
rectangles in M and N is shown in O and P. Epha4 expression was
significantly increased in r1, r2 and r3 of the Msx1/2
mutant (arrowheads in P). Scale bars: in B (for A,B), F (for E,F), H (for
G,H), J (for I,J), L (for K,L), 0.2 mm; D (for C,D), 0.1 mm.
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