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Fig. 5. Expression of fgf8 and the Fgf-target gene spry4, during
early eye development. At the 5-somite stage, fgf8 and spry4
are co-expressed in the telencephalon dorsal to the diencephalic evagination
zone of the optic vesicles (A-D) in wild-type embryos. spry4
expression extends from the telencephalon into the diencephalon, including the
proximal future nasal part of the evaginating optic vesicle (arrowheads in D)
and is found in the nasal placode precursor cells (npp) (D), surrounding the
telencephalon at this stage. (E,F) In ace, telencephalic and
diencephalic spry4 expression is reduced (arrowheads in F), but
expression in the nasal placode precursor cells is unaffected. Orientation of
dorsal views (A,C,E,) indicated in A; orientation of transverse sections at a
intermediate anterior-posterior level of the optic vesicle (B,D,F) indicated
in B. A, anterior; P, posterior; Pr, proximal; Di, distal; D, dorsal; V,
ventral; tel, telencephalon; ov, optic vesicle; npp, nasal placode precursors.
Broken lines represent outlines of the optic vesicle (A,C,E,) and neural tube
(B,D,F).
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