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Fig. 2. NsCre:ShhFl/Fl mutants lose the expression of Shh responsive genes at the MGE-LGE sulcus, but maintain other aspects of MGE patterning. (A-C') In situ hybridization of E12.5 forebrain for (A,A') Gli1, (B,B') Nkx6.2 and (C,C') Oct6 in wild-type (A,B,C) and NsCre:ShhFl/Fl mice (A',B',C'). (D-F') Immunofluorescence of E12.5 forebrain for (D,D') Gsh2, (E,E') Dlx2 and (F,F') Olig2 in NsCre(–):ShhFl/wt control (D,E,F) and NsCre:ShhFl/Fl mutant mice (D',E',F'). Despite the loss of expression of Gli1 and Nkx6.2 in the mutant MGE, other markers of MGE patterning in the VZ (Olig2) and SVZ (Oct6) appear to be unaltered. Scale bar: 200 µm.





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