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First published online November 10, 2005

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When signalling sequence matters

The hypothalamus controls temperature, hunger and many other physiological functions in animals, but the signals that control the development of hypothalamic neurons are poorly understood. Ohyama and colleagues remedy this by reporting that the sequential action of sonic hedgehog (Shh) and bone morphogenetic protein 7 (Bmp7) directs the differentiation of hypothalamic dopaminergic neurons in chick embryos (see p. 5185). By examining the expression of hypothalamic regional markers in embryo explants exposed to Shh and Bmp7, and to inhibitors of these molecules, the researchers show that the induction of dopaminergic neuron identity is initiated by Shh signalling. Bmp7 then acts on cells that have been ventralised by Shh, including unexpectedly postmitotic cells, to generate hypothalamic neurons. Finally, the researchers report that Shh and Bmp7 in combination are sufficient to direct neural progenitors derived from mouse embryonic stem cells to a hypothalamic dopaminergic fate.

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Related articles in Development:

Directed differentiation of neural cells to hypothalamic dopaminergic neurons

Kyoji Ohyama, Pamela Ellis, Shioko Kimura, and Marysia Placzek
Development 2005 132: 5185-5197. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?