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First published online November 10, 2005

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Fgf8 noses into olfactory development

Fibroblast growth factors (FGFs) promote the proliferation, differentiation and survival of most neural cell types during development. Kawauchi et al. now report that Fgf8 expression is essential for neurogenesis in mouse olfactory epithelium (see p. 5211). Around mid-gestation, the olfactory placodes (epithelial patches on the head of developing embryos) invaginate to form nasal pits in which neurogenesis occurs. The researchers show that Fgf8 is expressed in the rim of invaginating nasal pits - they call this region the morphogenetic centre. They then demonstrate that early inactivation of the Fgf8 gene in the olfactory epithelium leads to the apoptosis of cells in the morphogenetic centre. Consequently, nasal invagination ceases and olfactory neurogenesis fails. The researchers conclude that Fgf8 expression is crucial for the morphogenesis of the nasal cavity, and for the survival and subsequent expansion of the stem cell population that generates olfactory neurons.

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Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse

Shimako Kawauchi, Jianyong Shou, Rosaysela Santos, Jean M. Hébert, Susan K. McConnell, Ivor Mason, and Anne L. Calof
Development 2005 132: 5211-5223. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?