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Fig. 8. Defective axon guidance in the src-1(cj293) mutant. (A-F) The
typical axon trajectories of the AVM (A,B), ALM (C,D) and CAN (E,F) neurons in
the wild-type (A,C,E) and src-1(cj293) mutant were visualized as
described in the materials and methods. Defects in the nerve ring branch of
the AVM trajectory (B), the ALM cell body and its trajectory (D) and the CAN
cell body and posterior axon trajectory (D) were observed. The percentages of
worms with defective axon guidance and the total numbers of worm observed (n)
are indicated in each panel. Scale bar: 20 µm. (G) Schematic representation
of the PVM axon trajectory in a wild-type worm. (H-K) The defective PVM axon
trajectory in the src-1(cj293) mutant. The defects were classified
into two patterns as indicated schematically at the bottom of the panels. Some
of the PVM axons in the src-1(cj293) mutant turn in the posterior
direction on the ventral cord and then makes a reverse turn in the anterior
direction (J), while others turn in the posterior direction on the ventral
cord and continues in that direction (K). The percentages of worms with the
various PVM axon trajectory patterns are shown. Scale bar: 20 µm.
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