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Fig. 4. Gli3–/– limbs are delayed in endochondral
ossification. Serial sections of E16.5 wild-type (A,C,E,) and
Gli3–/– (B,D,F) limbs were hybridized with
riboprobes as indicated. (A-D) Expression of Ihh and Col10a1
reveals normal regions of prehypertrophic and hypertrophic chondrocytes. (A,B)
The overall size of the radius in wild-type mice (light-green bar) is reduced
in Gli3–/– mutants (dark-green bar,
P=0.0036), and the ossification is slightly delayed (compare dark-
and light-blue double-headed arrows in wild-type and
Gli3–/– limbs, respectively). (E,F) The
expression of Ptch is unchanged in
Gli3–/– limbs.
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