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Fig. 7. Differentiation of distal chondrocytes is accelerated in
Col2a1-Ihh mice. Sections of E16.5 wild-type (A,C) and
Col2a1-Ihh (B,D) limbs were hybridized with Fgfr1 (A,B) and
Fgfr3 (C,D) riboprobes. (A1-D1) are higher magnifications of boxed
regions in A-D, the dashed line in B,B1 demarcates the end of the radius,
which is partially fused with the carpal navicular lunare in
Col2a1-Ihh mice. The domain of Fgfr1 expression is reduced
in Col2a1-Ihh mice (A,B, green arrow). The domain of Fgfr3
expression is broadened and shifted towards the end of the skeletal elements
in Col2a1-Ihh mice (C,D, blue arrow in C1,D1). (E) The Fgfr1
expression domain (green arrow in A,B) is reduced in Col2a1-Ihh limbs
(*P=0.003, n=3) whereas the domain of Fgfr3
expression (blue arrow in C,D) is strongly expanded compared to that of
wild-type limbs (**P=0.007, n=3).
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