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Fig. 6. The N-terminal region of Ubx protein is required for the activation of tsh transcripts in the head epidermis. (A-E) Shown are the head and anterior thorax of late stage 11 embryos, hybridized with a tsh antisense probe. (A) In wild-type embryos, tsh is transcribed in the epidermis of parasegment 3 (as well as in parasegments 4-13, not shown). (B) Ectopic wild-type Ubx induces tsh transcripts in the clypeolabrum (cl), the procephalon (pc), and the mandibular (Md) and maxillary (Mx) segments. (C) Ectopic Ubx ${Delta}$ 2-19 activates very low levels of tsh transcripts in the pc and cl, and in only a few cells of the Md and Mx segments. (D,E) Ectopic Ubx ${Delta}$ 20-61 and Ubx ${Delta}$ YPWM proteins activate tsh transcripts at similar levels and in similar pattern to wild-type Ubx, but with less uniformity. (F) Quantitation of ectopic protein expression levels and tsh transcripts, averaged over the entire head region. Error bars: 95% confidence intervals. (G) Alignment of the N termini of the Ubx proteins from Drosophila melanogaster (Dm), Tribolium castaneum (Tc), Porcellio scaber (Ps) and Artemia franciscana (Af). Ten out of the 18 amino acid residues eliminated in the Ubx ${Delta}$ 2-19 mutant are identical in the four Ubx homologs.

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