spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online November 28, 2005

Development 132, 2401e (2005)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Wnt3a: telling left from right

Building the 3D vertebrate body is a feat of cellular engineering during which each axis is laid down at the correct orientation to the other two axes. The left-right (LR) axis is determined last under the control of the node, an embryonic structure that also controls trunk elongation. On p. 5425, Nakaya and co-workers reveal that Wnt3a, which is expressed in the node, is required for LR asymmetry determination in the mouse embryo. They show that the heart and other anterior internal organs in Wnt3a-/- embryos have defects that arise from the incorrect specification of the LR axis. They also report that Wnt3a regulates the expression of the left determinant gene Nodal, as well as of several other genes involved in trunk elongation through the Notch signalling pathway. Thus Wnt3a functions in the trunk organizer to coordinate patterning and morphogenesis along multiple body axes.



Related articles in Development:

Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation
Masa-aki Nakaya, Kristin Biris, Tadasuke Tsukiyama, Shaulan Jaime, J. Alan Rawls, and Terry P. Yamaguchi
Development 2005 132: 5425-5436. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content