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First published online November 28, 2005

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Wnt3a: telling left from right

Building the 3D vertebrate body is a feat of cellular engineering during which each axis is laid down at the correct orientation to the other two axes. The left-right (LR) axis is determined last under the control of the node, an embryonic structure that also controls trunk elongation. On p. 5425, Nakaya and co-workers reveal that Wnt3a, which is expressed in the node, is required for LR asymmetry determination in the mouse embryo. They show that the heart and other anterior internal organs in Wnt3a^-/- embryos have defects that arise from the incorrect specification of the LR axis. They also report that Wnt3a regulates the expression of the left determinant gene Nodal, as well as of several other genes involved in trunk elongation through the Notch signalling pathway. Thus Wnt3a functions in the trunk organizer to coordinate patterning and morphogenesis along multiple body axes.

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Related articles in Development:

Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation

Masa-aki Nakaya, Kristin Biris, Tadasuke Tsukiyama, Shaulan Jaime, J. Alan Rawls, and Terry P. Yamaguchi
Development 2005 132: 5425-5436. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?