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First published online November 28, 2005

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Fate determination by microRNA control

The patterns of gene expression that define differentiated cells are controlled by complex regulatory networks of transcription factors and microRNAs. Johnston and Hobert now identify a new component of the network that controls left/right asymmetry in the gustatory neurons of Caenorhabditis elegans - the zinc finger transcription factor lsy-2 (see p. 5451). The nematode's gustatory neurons ASE left (ASEL) and ASE right (ASER) are morphological mirror images but have left/right asymmetric functions. The researchers show that, although lsy-2 is expressed in both ASEL and ASER, it is a permissive factor for the expression of the microRNA lsy-6 in ASEL - lsy-6 is a component of the regulatory network that controls ASEL fate. By identifying a factor that is involved in the spatial expression of a microRNA gene, the researchers provide an important new insight into how terminal cell fates are specified.

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Related articles in Development:

A novel C. elegans zinc finger transcription factor, lsy-2, required for the cell type-specific expression of the lsy-6 microRNA

Robert J. Johnston, Jr and Oliver Hobert
Development 2005 132: 5451-5460. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?