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First published online November 28, 2005

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Arrow targets Wingless for degradation

An important way of controlling certain signalling pathways, such as the Wingless (Wg) pathway, is through the endocytic degradation of extracellular ligands. Now, Piddini et al. report that, in Drosophila wing imaginal discs, the degradation of Wg (which is required to form a gradient of this morphogen) is cooperatively controlled by Arrow and Frizzled2, two receptors involved in Wg signal transduction (see p. 5479). The researchers show that although Frizzled2, a seven-transmembrane receptor, stimulates the internalisation of Wg in wing imaginal discs and cultured cells, it does not take Wg to a degradative compartment. This requires the LDL receptor-related protein Arrow, which stimulates the targeting of the Frizzled2-Wg complex to lysosomes for degradation. The separation of ligand capture and degradation between two receptors, the researchers suggest, could help to generate a reliable concentration gradient of Wg and other morphogens during development.

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Related articles in Development:

Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs

Eugenia Piddini, Francis Marshall, Laurence Dubois, Elizabeth Hirst, and Jean-Paul Vincent
Development 2005 132: 5479-5489. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?