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Fig. 4. pelo modulates dpp pathway activity, but is dispensable for bam suppression in GSCs. Germaria (A-D) are labeled for Hts (red) and DAPI (nuclei, blue). (A) A germarium showing that dpp overexpression causes accumulation of GSC-like cells. (B) A germarium showing that removal of one copy of functional pelo results in partial suppression of the GSC-like tumor phenotype induced by dpp overexpression, which is evidenced by the presence of egg chambers. (C,D) Germaria showing that removal of both copies of pelo partially (C) or completely (D) suppresses the tumor phenotype. (E,E') A germarium labeled for GFP (green) and lacZ (red), showing that a marked pelo mutant GSC (broken lines, black in E) downregulates dad-lacZ expression (red, E') in comparison with its neighboring wild-type GSC (solid circle, green). (F,F') A germarium labeled for GFP (green) and lacZ (red), showing that a marked pelo mutant GSC (broken lines, black in F) does not upregulate bam-GFP expression (F') in comparison with its neighboring wild-type GSC (solid circle, red). Scale bars: 10 µm.





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