|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 6. Summary of findings about the required role of Tcf/Lef genes in
Xenopus early mesoderm development. Tcf3 gene function is
predominantly required in a transcriptional repressor role for mesoderm
induction; while Tcf1 gene function is also required for mesoderm induction,
but predominantly in a transcriptional activator role. However, Tcf1 gene
function has another required role, also mainly as an activator, in
ventrolateral mesoderm patterning, independent of its role in mesoderm
induction. Lef1 gene function is also required as an activator for
ventrolateral mesoderm patterning. Perturbing Tcf3 gene function also affects
ventrolateral mesoderm induction, but only in a roundabout way, i.e. because
ventrolateral mesoderm patterning is dependent on prior mesoderm induction,
which is dependent of normal Tcf3 function.
|
