|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 3. lsy-2 encodes a C2H2 zinc finger protein. (A) Sequence alignment
of lsy-2 and its paralog, lsl-1, and their C.
briggsae orthologs. Conserved cysteines and histidines in the C2H2
fingers (grey boxes) are indicated in red. A putative nuclear localization
sequence is underlined. Mutant alleles are indicated in blue. (B) Alignment of
the first three C2H2 fingers of LSY-2 with representative members of the
SP1/KLF-like family (Kaczynski et al.,
2003) and two other SP1/KLF-like C. elegans proteins.
These two proteins are the top hits when BLAST searching the C.
elegans genome for human or Drosophila SP1-like proteins. Other
KLF-like proteins have previously been noted in worms
(Oates et al., 2001) and are
not shown here. Residues in red and blue are 100% conserved; residues in green
are partly conserved. Sequences of human proteins are from Kaczynski et al.
(Kaczynski et al., 2003). (C)
The linkers between C2H2 zinc fingers in the triple motif in LSY-2 have a
similar length and share conserved amino acids with known transcription
factors of the SP1/KLF family. One representative member of each of the three
subgroups of human SP1/KLF proteins is shown.
|
