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Fig. 9. Mammillary body neurons survive until the end of gestation in
Sim1/Sim2 double mutants. Coronal sections through the MB of E18.5
with various dosage of Sim1/Sim2, as indicated, hybridized with
Sim1 (A,B), Lhx1 (C,D) and Foxb1 (E-H) probes.
Sim1 and Lhx1 expression is maintained in the MB of
Sim1/Sim2 double mutants. By contrast, Foxb1 expression is
dramatically reduced in Sim1/Sim2 double mutants but not in embryos
with at least one allele of Sim1/Sim2. Of note, the apparent
smaller sizes of the MBs shown in G and H reflect different planes of
section.
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