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Fig. 7. Myoferlin null muscle regenerates less effectively and shows more
fibrofatty infiltrate than does littermate control muscle after cardiotoxin
injection. (A) In Mason Trichrome-stained sections of gastrocnemius muscles 9
days after cardiotoxin injection, fatty infiltrates appear white (arrowheads)
and fibrotic tissue appears blue (arrows). Scale bar: 100 µm. (B) In
sections stained with Oil Red O and Hematoxylin counterstain 13 days after
injection, areas of fatty infiltrate appear as round white cells with orange
droplets in the myoferlin null tissue. Scale bar: 50 µm. (C) ImageJ was
used to quantify the area covered by fatty infiltrates and fibrotic tissue in
four images of Trichrome-stained tissue, such as those shown in A, at each of
three time points, days 9, 11 and 13 post-injection. Significantly more muscle
was replaced with fibrofatty tissue in myoferlin null mice than in wild
type.
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