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First published online January 14, 2005

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Encapsulating kidney capsule functions

Kidney morphogenesis depends on defined zones of induction (at its edge) and differentiation (in its interior) that lead to its final radial pattern. Levinson and colleagues now report (see p. 529) that deletion of the transcription factor Foxd1 in mice causes the loss of these zones and the delayed formation and disorganisation of the nephrogenic and ureteric compartments by disrupting the normal formation of the renal capsule. In Foxd1-null mutant embryos, a single layer of Foxd1-positive stroma in the renal capsule is replaced by a thicker, heterogeneous cell layer, in which some cells express Bmp4. This induces ectopic Smad signalling in the nephron progenitors, disrupting their early patterning and, through reciprocal signalling interactions, inducing ureteric tree patterning. Thus, the renal capsule not only delineates the kidney but also acts as a barrier to inappropriate exogenous signals while providing endogenous signals needed for normal radial patterning.

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Related articles in Development:

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

Randy S. Levinson, Ekatherina Batourina, Christopher Choi, Marina Vorontchikhina, Jan Kitajewski, and Cathy L. Mendelsohn
Development 2005 132: 529-539. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?