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Fig. 3. Hoxb4 and Hoxd4 regulate the hindbrain expression of
Rarb at late but not at early stages. All panels show the expression
of Rarb mRNA in dorsal views of E9.0-E10.5 embryos lacking from 0 to
4 wild-type alleles of Hoxb4 and Hoxd4. The wild-type
position of the neural Rarb expression border at r6/r7 (arrowhead) is
indicated. (A) E9.0 embryos with Hoxb4+/-;
Hoxd4-/- (left) and Hoxb4-/-;
Hoxd4-/- (right) genotypes showing wild-type patterns of
Rarb expression. At this intermediate stage, although the
Rarb neural border lies in the vicinity of the forming r6/r7
junction, it is not as sharp as at E9.5. (B) E10.5
Hoxb4+/+; Hoxd4-/- embryo with a
normal neural border of Rarb expression at r6/r7. (C,D) E9.5 embryos
that are wild type (C) or Hoxb4-/-;
Hoxd4-/- (D) showing abnormal regression of the Rarb
border associated with loss of function of both Hox paralogues. (E,F)
E10.5 embryos that are wild type (E) or Hoxb4-/-;
Hoxd4-/- (F), showing that, by this late stage, removing the
activity of both Hox paralogues leads to loss of most Rarb
expression from the hindbrain.
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