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Fig. 6. The choroid plexus is the likely source of CNTF and LIF that acts upon VZ precursors in the LGE of the developing forebrain. (A,B) Immunostaining for CNTF in the E14.5 forebrain revealed strong expression by the choroid plexus (CP; arrow in B) and at the base of the choroid plexus (large arrowhead in B). Immunoreactive cells were also observed in the mantle zone (small arrowhead in B). Similar staining was not observed in control sections labeled with goat IgG (A). (C,D) LIF immunoreactivity was observed in the choroid plexus (arrow in D), but not other regions of the E14.5 ventral forebrain. Similar staining was not observed in control sections labeled with rabbit IgG (C). (E) The expression of both CNTF and LIF in the E14.5 choroid plexus was confirmed by RT-PCR analysis (n=3). (F) These findings suggest a model in which the choroid plexus secretes CNTF and LIF, establishing a gradient of VZ to SVZ precursor cell differentiation from P1 to P5 precursors within the LGE germinal zone. GE, ganglionic eminence; T, thalamus; LGE, lateral ganglionic eminence; CTX, cortex. Scale bar: 100 µm.





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