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First published online January 27, 2005

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Found: an elusive member of the Hh signalling pathway

Despite the remarkable conservation of the Hedgehog (Hh) signalling pathway through evolution, Costal2 (Cos2), a vital component of this pathway in flies, has escaped detection in vertebrates. But now, Tay et al. report the identification of the first vertebrate homologue of Cos2, which they cloned from zebrafish by virtue of its sequence similarity to fly Cos2 (see p. 625). In morpholino knockdown experiments, the authors show that decreased cos2 levels cause ectopic Hh signalling, as expected from its role in flies where this kinesin-related protein is thought to assemble a protein complex, ultimately leading to the Cubitus interruptus (Ci)-mediated repression of Hh target genes. In vitro, zebrafish Cos2 can complex with Gli1, the fly homologue of Ci. Together with the mouse and human Cos2-like sequences reported here, these findings should shed new light on the mechanics of Hh signalling in vertebrates.

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Related articles in Development:

A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo

Shang Yew Tay, Philip W. Ingham, and Sudipto Roy
Development 2005 132: 625-634. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?