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First published online January 27, 2005

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Getting specific with imprinting

The deletion of the chromatin-remodelling protein Lsh in mice causes loss of DNA methylation – a process thought to be responsible for the expression of certain genes in a heritable, parent-specific manner. These so-called imprinted genes are associated with differentially methylated regions (DMRs) that are established during gametocyte development and maintained through embryogenesis. On p. 635, Fan and colleagues now examine whether loss of Lsh also affects imprinting. They report that in Lsh-null mouse embryos, imprinting is maintained at all loci examined, except at the cell cycle inhibitor Cdkn1c gene. Reactivated expression of the paternal copy of Cdkn1c correlates with a loss of methylation at a DMR in its promoter, where the authors show Lsh binds in vitro. These findings suggest that although Lsh is not required for the genome-wide maintenance of imprinting, it may be required for the de novo methylation of specific sites.

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Related articles in Development:

Lsh controls silencing of the imprinted Cdkn1c gene

Tao Fan, John P. Hagan, Serguei V. Kozlov, Colin L. Stewart, and Kathrin Muegge
Development 2005 132: 635-644. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?