spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online January 27, 2005

Development 132, 405e (2005)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Building the right embryonic scaffold


During early Xenopus development, embryonic cells assemble a cortical actin network that maintains an embryo's overall shape and rigidity. But how does each cell assemble an appropriately patterned and dense network? Lloyd et al. now report on p. 805 that lysophosphatidic acid (LPA) – a bioactive lipid that influences actin networks and cellular morphology – plays an important role in this process. Their findings show that if the LPA1 and LPA2 receptors are overexpressed in the whole frog embryo (LPA2 is newly identified here), denser actin networks develop. Conversely, depleting LPA receptor levels in early embryos reduces network density. When LPA is added to dissociated embryonic cells, or when they are allowed to reaggregate, a denser, more normal actin network replaces the coarser network seen. The authors conclude that intercellular signalling between cells is required to maintain a normally patterned and dense actin network to support the developing embryo, and that this signalling requires LPA.


Related articles in Development:

Lysophosphatidic acid signaling controls cortical actin assembly and cytoarchitecture in Xenopus embryos
Brett Lloyd, QingHua Tao, Stephanie Lang, and Chris Wylie
Development 2005 132: 805-816. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content