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Fig. 5. Floorplate differentiation fails in mol-/- but not in
smu-/- embryos. Lateral (A-I) and dorsal (J-O) views of
the trunk floorplate in 36 hpf (A-I) and 24 hpf (J-O) wild-type,
mol-/- and smu-/- embryos. (A-O)
Expression of floorplate differentiation markers col2a1, min1, min2,
arx and ctgf is similar in wild-type and
smu-/- embryos but expression is severely reduced or
absent in the mol-/- embryos (despite the presence of
floorplate cells, arrowhead in B). Although floorplate expression is retained,
the somitic expression of arx and ctgf is lost in the
smu-/- mutants (L,O). fp, floorplate; hy, hypochord; nc,
notochord.
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