|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 9. A model of restricted Wg movement along cell surface. Secreted
extracellular Wg is bound and stabilized by glypicans Dally and Dlp on the
cell surface. The differential concentration of Wg from producing cells to
receiving cells drives Wg diffusion along cell surface to more distal cells
through disassociation/re-association with HSPGs. In the absence of Dally and
Dlp, the Wg protein can no longer move further. It either stays on cell
membrane or diffuses into disc lumen, or is degraded. The thin black arrows at
the top of this diagram indicate the displacement of Wg from one GAG chain to
another. The double-headed arrow indicates the lateral movement of glypicans
on the cell membrane.
|
