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Fig. 1. The DM sheet gives rise to derivatives that colonize both the dermis and
the myotome. (A) Five hours after electroporation, GFP-expressing cells
(green) are located in the epithelial DM sheet. (B,C) At E5, GFP-labeled cells
are present in the desmin-positive myotome (red) intermingled among desmin+
fibers. Labeled cells are also present in the dermis. At this stage, the
dermo-1 mRNA signal (blue reaction product) is predominantly
expressed in the superficial domain of the young dermis close to the ectoderm,
whereas GFP-expressing cells are widespread throughout the entire dermis. (C)
High magnification of the insert in B. Note that the GFP-labeled cells in
myotome and dermis are located at corresponding mediolateral regions, further
substantiating the proposed coherent mode of DM development
(Ben-Yair et al., 2003). D,
dermis; DM, dermomyotome; M, myotome; NT, neural tube. Scale bar: 20 µm in
A; 180 µm in B; 50 µm in C.
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