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Fig. 3. Proliferation defect of OB interneuron progenitors in
Arx-deficient mice. (A-F) Coronal sections of E14.5 olfactory bulb
(OB; A,B), rostral migratory stream (RMS; C,D) and ganglionic eminence (E,F)
of wild-type (A,C,E) and Arx-deficient (B,D,F) mice that incorporated
BrdU for 1 hour were labeled with anti-BrdU antibody. BrdU-labeled cells were
observed in the subventricular zone (SVZ) of wild-type and mutant mice. (G)
Quantification of BrdU-positive cells in wild-type and mutant OB. Values are
mean±s.e.m. (n=3, t-test, P<0.01, marked
with double asterisks). (H) Quantification of BrdU-positive cells in wild-type
and mutant RMS and SVZ. Values are mean±s.e.m. (n=3,
t-test, P<0.05, marked with asterisk). Scale bar: 200
µm.
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