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Fig. 4. External phenotype of the MFCS1 KO mouse. (A,B) The limbs of the MFCS1 KO
embryos at E12.5 are extremely reduced. (C,D) In the KO embryos at E14.5, the
distal ends of the limbs becomes very thin. (E) A 10-day post-natal MFCS1 KO
homozygote appears quite healthy, except for the limb abnormality. (F) The
body size of a 3-week-old MFCS1 KO homozygote (right) is comparable to that of
wild-type (left). (G-J) Magnified pictures of the forelimbs (G,I) and
hindlimbs (H,J) in the MFCS1 KO homozygote. The autopod is not recognizable in
the forelimbs. In the hindlimbs, only one digit with a nail is observed (H).
On the surface of the ventral side of the digit, pad-like tissue is observed
(J).
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