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Fig. 2. Histological and morphological examination of
Lfng–/– ovaries. (A) Ovaries from 4-week-old
Lfng+/– and Lfng–/–
mice; null ovaries are smaller and developing follicles are obvious in both.
(B) The reproductive tracts of 7-week-old Lfng+/–
and Lfng–/– mice; all structures were present
and no gross abnormalities were noted. (C,D) Histological sections of neonatal
ovaries stained with Hematoxylin and Eosin. Primordial follicles are evident;
however, the Lfng null ovary (C) is smaller than the
Lfng+/– ovary (D) and the morphology is not as well
organized. (E-J) Histological sections of ovaries from 42-day-old
Lfng–/– mice. Many abnormal follicles were
noted. Some large follicles had smaller follicles within their boundaries (E,
black arrow). There were follicles that shared theca or had incomplete theca
(F, black arrowheads). There were polyovular follicles containing two or three
oocytes (F, red arrows; G,H). There were also many large lutealinized
follicles with trapped oocytes (I,J). Scale bars: 100 µm.
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