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Fig. 1. Restored cardiac/vascular function in N-cadherin-deficient embryos rescues formation of the dorsal pancreas. Histochemically and immunohistochemically stained sections of the dorsal pancreatic region from 9.5 dpc wild-type (A,D,G,J,M), Cdh2^-/- (B,E,H,K,N), cardiac-rescued Cdh2^-/- (Cdh2^-/-Tg) (C,F,I,L,O) embryos, and from 10.5 dpc wild type (P) and cardiac-rescued Cdh2^-/- (Q) embryos. (A-C) Sections were stained with hematoxylin and eosin (HE). (D-Q) Immunohistochemical staining of sections with antibodies against Isl1 (D-F,P,Q), Pdx1 (G-I), N-cadherin (Cdh2; J-L; inset shows expression of the Cdh2 transgene in the heart) and CD31 (M-O). Despite the lack of N-cadherin expression within the dorsal pancreatic mesenchyme, dorsal pancreas formation is rescued in cardiac-rescued Cdh2^-/- embryos (G-L). The dorsal pancreatic endoderm and dorsal aorta are indicated by broken line and asterisk, respectively. Scale bars: in A, 30 µm for A-C; in D, 20 µm for D-O; in P, 20 µm for P,Q; inset in L, 40 µm.

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