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Fig. 6. Blood vessels are present but disorganized around Cdh2-/- pancreatic buds independent of the presence or absence of S1P. Pancreatic-gut explants from wild type (WT; A) and Cdh2-/- embryos incubated with beads soaked in PBS (B) or S1P (C) were analysed for the presence and distribution of blood vessels by double immunostainings with CD31 (blue) and Pdx1 (brown) antibodies. Higher magnification of the pancreatic region in A, B, and C is shown in D, E, and F, respectively. Whereas blood vessels were present nearby the pancreatic endoderm independent of the genotype and presence of S1P, N-cadherin-deficiency resulted in a disorganised network of blood vessels. S1P stimulated an overall growth of the pancreatic-gut explants, including endoderm, mesenchyme and blood vessels. db, dorsal pancreatic bud; vb, ventral pancreatic bud; gb, gall bladder. Both the dorsal (left) and ventral (right) pancreas is delineated with red broken lines. Scale bars: in A, 100 µm for A-C; in D, 30 µm for D-F.





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