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Fig. 4. Frequency and absolute number of (A) osteogenic, (B) adipogenic and (C)
chondrogenic progenitors in hematopoietic sites through development.
Osteogenic and adipogenic progenitor frequencies and numbers were determined
based on the number of colonies displaying the appropriate phenotype.
Chondrogenic progenitor frequency and number was determined based on the
number of cartilage foci after 21 days of aggregate culture. Data are
expressed as mean±s.d. (n=3 to six independent experiments).
Absolute number determinations in the neonatal and adult BM used the following
values: newborn BM, 9.8 x107 cells; adult BM, 30.0
x107 cells (Harrison,
1993). These values were extrapolated from those of Stewart et al.
(Stewart et al., 1993).
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