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First published online February 10, 2005

Development 132, 501e (2005)
© The Company of Biologists Limited
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In this issue

Myc maintains ES cell pluripotency

The LIF (leukaemia inhibitory factor)/STAT3 signalling pathway is crucial for the self-renewal of mouse embryonic stem (ES) cells, but the downstream effectors of this pathway are not known. Now, Cartwright and co-workers show that LIF/STAT3 controls mouse ES cell self-renewal and pluripotency through the transcription factor Myc (see p. 885). The researchers report that Myc is a target gene for STAT3 - a transcription factor activated by LIF signalling - in these cells. They show that Myc mRNA levels in ES cells fall rapidly following LIF withdrawal and that the Myc protein becomes phosphorylated on threonine 58, making it a target for degradation by GSK3ß. Based on their results, the researchers propose that LIF and STAT3 control ES cell self-renewal and pluripotency by regulating Myc activity, thus identifying Myc as a key regulator of mouse ES cell self-renewal.


Related articles in Development:

LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
Peter Cartwright, Cameron McLean, Allan Sheppard, Duane Rivett, Karen Jones, and Stephen Dalton
Development 2005 132: 885-896. [Abstract] [Full Text]  




This Article
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