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First published online February 10, 2005

Development 132, 504e (2005)
© The Company of Biologists Limited
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In this issue

Ploughing a straight furrow

Precise changes in plasma membrane shape underlie many morphogenetic processes. During the cellularisation of Drosophila embryos, furrow canal formation - a specialised process of membrane invagination - and actin cytoskeleton reorganisation enclose the nuclei of the syncytial blastoderm into cells. On p. 1009, Großhans and colleagues report that the guanyl-nucleotide exchange factor RhoGEF2 and the formin Diaphanous (Dia) play a crucial role in regulating the position, shape and stability of the furrow canal by controlling actin filament assembly. They show that RhoGEF2 or dia mutant embryos have enlarged furrows - both proteins normally localise to the invagination site before furrow formation - and that F-actin levels at the furrow canal are reduced in these mutants. As RhoGEF2 and dia appear to act in a parallel genetic pathway to nullo and sry-{alpha}, early furrow canal markers that are involved in junction formation, these two pathways might control complementary aspects of furrow canal formation.Go



Related articles in Development:

RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation
Jörg Großhans, Christian Wenzl, Hans-Martin Herz, Slawomir Bartoszewski, Frank Schnorrer, Nina Vogt, Heinz Schwarz, and H.-Arno Müller
Development 2005 132: 1009-1020. [Abstract] [Full Text]  




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