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First published online February 10, 2005

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E-cadherin: expanding the fish embryo

The first morphogenetic movement of teleost embryos is epiboly, when the embryonic cell mass spreads over the yolk. Kane and co-workers now provide new insights into this process in their analysis of zebrafish mutants with arrested epiboly (p. 1105). These mutants were found to have different versions of the half baked (hab) locus, which the authors report here encodes the zebrafish homolog of E-cadherin. They identify two cell layers in the epiblast, the outer of which expresses hab mRNA at higher levels, and show that during normal epiboly, inner layer cells radially intercalate into the outer cell layer and flatten, thus expanding the area of the epiblast. In hab mutants, the interior cells intercalate normally but fail to flatten and sometimes return to the inner layer. The researchers conclude that E-cadherin is required for the cell movements of epiboly and possibly for similar movements in mammalian embryos.

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Related articles in Development:

Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly

Donald A. Kane, Karen N. McFarland, and Rachel M. Warga
Development 2005 132: 1105-1116. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?