QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online February 10, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Oncogene effects and developmental state

A woman's susceptibility to breast cancer is influenced by the timing of normal developmental events, such as her first full-term pregnancy, suggesting that the effects of oncogene activation might be modulated by the developmental state of the breast. On p. 1147, Blakely and colleagues provide in vivo molecular evidence for this hypothesis by showing a developmental stage-specific effect of aberrant MYC activation in the mouse mammary gland. The researchers use a doxycycline-inducible transgenic mouse model to show that MYC overexpression during a specific 72-hour window in mid-pregnancy inhibits post-partum lactation. Unexpectedly, MYC overexpression does this by inducing precocious lactation via Stat5 activation; the absence of a suckling stimulus then causes the gland to involute prematurely to a non-lactating state. The researchers conclude that the oncogenic effects of MYC may similarly depend on the developmental stage of the mammary gland when the oncogene is activated.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Developmental stage determines the effects of MYC in the mammary epithelium

Collin M. Blakely, Louis Sintasath, Celina M. D'Cruz, Kristina T. Hahn, Katherine D. Dugan, George K. Belka, and Lewis A. Chodosh
Development 2005 132: 1147-1160. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?