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Fig. 4. Asymmetric expression of Raldh genes in the retina is maintained in Bmpr1a-/fx; Bmpr1b+/-;Cre mutants. In situ hybridization on coronal sections of E12.5 embryos with dorsal towards the top. Arrows indicate the domains of expression within the retina. (A,C) The transcripts for genes encoding retinoic acid synthesizing enzymes Raldh1 (Rldh1a1) (A) and Raldh3 (Rldh1a3) (C) are asymmetrically expressed in the retina with high levels dorsally and ventrally, respectively. In addition, they are also expressed at low levels in the surface ectoderm surrounding the eye region (A,C), the lens (A) and the dorsal RPE (C). (B,D) The expression pattern is not significantly altered in the Bmpr1a-/fx;Bmpr1b+/-;Cre mutant embryos. le, lens; nr, neuroretina; rpe, retinal pigmented epithelium; se, surface ectoderm. Scale bar: 100 µm.





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