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Fig. 1. Blimp1 expression in the early mouse embryo. Whole-mount in situ hybridization identifies Blimp1 expression domains at (A) early streak, (B) mid-late streak, (C) late streak, (D) no allantoic bud, (E) early allantoic bud and (F) early headfold stages. (A) In the pre-gastrulation embryo, Blimp1 is expressed in a sub-population of visceral endoderm overlying the proximal epiblast. (B,C) At mid- to late streak stage, Blimp1 is detected in the anterior visceral endoderm (AVE, asterisk), and in the nascent primordial germ cells (PGCs) present in the incipient allantois (arrow). (D,E) At later stages, Blimp1 transcripts mark the prechordal plate and anterior definitive endoderm [labeled collectively as anterior axial mesendoderm (ame)], and PGCs present in the growing proximal posterior extraembryonic mesoderm (arrow). (F) At the early headfold stage (EHF), expression is lost from the midline but persists in the anterior definitive endoderm of the foregut pocket, and within the cluster of individual PGCs at the base of the allantois (arrow). ES, early streak; MS, mid streak; LS, late streak; OB, no allantoic bud; EB, early allantoic bud stages. Embryos are shown anterior to the left.





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