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Fig. 7. Representative HE-staining of the developing eyes of mouse embryos at E12.5
(A) and E18.5 (B). Strikingly, the Wt1(-KTS)-deficient
embryos exhibited thinner retinas with fewer cells (A, parts c, d) than
age-matched normal mice (A, parts a, b). For comparison, the ocular phenotype
was less severe in embryos with inactivated Wt1(+KTS) (A,
parts e, f). (B) Abnormal morphology of the retina, in particular the reduced
cell density in the future ganglion cell layer, was clearly evident in
Wt1(-KTS)-deficient embryos at E18.5 (part d; compare with b
and f). Scale bars: 10 µm in B, parts b, d, f; 50 µm in A, parts b, d,
f; 50 µm in B, parts a, c, e; 100 µm in A, parts a, c, e.
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