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Fig. 8. Immunofluorescent labelling of Wt1 and Pou4f2 in the developing retinas of
mouse embryos at E18.5. Loss of retinal ganglion cells in mice with lack of
Wt1(-KTS) (C,D) is reflected in the reduction of Wt1- and
Pou4f2-positive cells compared with normal (Wt1+/+; A,B)
and Wt1(+KTS)-deficient (E,F) embryos. Notably, the class IV
POU domain factor, Pou4f2 (formerly Brn3b), was recently identified as a
transcriptional target of Wt1(-KTS)
(Wagner et al., 2002a;
Wagner et al., 2003). Scale
bars: 50 µm.
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