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Fig. 5. Evolutionary conservation of bap enhancer sequences and binding motifs. Shown are alignments of enhancer sequences of bap3.2 (D. melanogaster), bapV2 (D. virilis) and corresponding genomic sequences from D. yakuba (D. yak.), D. pseudoobscura (D. pse.) and D. ananassae (D. ana.). Colored boxes above the sequences with unbroken lines indicate the extent of DNAseI footprints on D. melanogaster sequences, boxes with black broken lines delineate highly conserved DNA stretches (C1 and C2), and colored boxes within the sequences denote core binding motifs for the respective binding factors. Nucleotides altered by in vitro mutagenesis for in vivo testing of binding site activities are shown on top of the D. melanogaster sequence (for Slp/Bin site mutations, see Fig. 7). For R1-R3 motifs, see text and Fig. 8. The R1 sequence is not readily detectable in the other species but the 5' region of bap3 (not shown) contains additional R-related motifs that are conserved and may have functionally redundant activities.

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